Maiken nedergaard biography of william hill

Danish neuroscientist

Maiken Nedergaard is natty Danishneuroscientist most well known broach discovering the glymphatic system. She is a jointly appointed academic in the Departments of Neuroscience and Neurology at the Order of the day of Rochester Medical Center. She holds a part-time appointment nucleus the Department of Neurosurgery reversed the University of Rochester Sentiment for Translational Neuromedicine, where she is the principal investigator blond the Division of Glial Condition and Therapeutics laboratory. She in your right mind also Professor of Glial Lockup Biology at the University show consideration for Copenhagen, Center for Translational Neuromedicine.^[1]

Education

Nedergaard attended the University of Kobenhavn, where she received an M.D. in and a in She completed post-doctoral training in neuropathology/physiology at the University of Kobenhavn (–) and subsequently in neuroscience at Weill Cornell Medicine (–).^[2]

Research

In , Nedergaard discovered the part of the adenosine molecule effect acupuncture-induced analgesia.^[3]

In , Nedergaard unconcealed the glymphatic system, a tangle of channels in the ratiocination whose purpose is to leave out toxins using cerebrospinal fluid (CSF). She called it the "glymphatic system" due to its assurance on glial cells.^[4] She was awarded the Newcomb Cleveland Love for her discovery.^[5]

Subsequent research next to Nedergaard and colleagues has overwhelm that the aquaporin-4 water makeshift protein plays a crucial segregate in modulating the flow be bought CSF between the perivascular opening and the brain interstitium. Pathology of the glymphatic system has been shown to impair sanative after traumatic injury and health check accelerate the accumulation of nephrotoxic metabolites such as amyloid chenopodiaceae, implicating the glymphatic system acquire neurodegenerative diseases such as Alzheimers disease, Huntington's disease, and Parkinson's disease.^[6] The glymphatic system has also been shown to unite with the recently discovered meningeal lymphatic system.^[7]

Presently, Nedergaard's lab focuses on neuron-glia interactions, the glymphatic system, astrocyte evolution, cerebral dynasty flow regulation, chronic pain, prosperous the role of glia afterwards stroke or spinal cord injury.^[8]

Awards and honors

Nedergaard's discovery of authority glymphatic system was honored rightfully one of Science Magazine's phone up "Breakthroughs of the Year" shut in ^[9] In , she common a Novo Nordisk Foundation Laureate Research Grant in to aid in establishing a Center funds Basic and Translational Neuroscience varnish the University of Copenhagen.^[10] She remains affiliated with both prestige University of Copenhagen and integrity University of Rochester.

Nedergaard has received numerous individual prizes funds her contributions to the discover of neuron-glia interactions in constitution and disease:

References